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. 2018 Jun 21;33:68–81. doi: 10.1016/j.ebiom.2018.06.012

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© 2018 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 4 — Spliceosome components and SFs show circadian transcriptional rhythms in primary and metastatic CRC.

Median-normalized, acrophase-ordered expression heatmap (left panel) and 3-h acrophase bins (right panel) of the circadian spliceosome components and SFs in SW480 (blue) (a) and SW620 cells (green) (b). (c) Expression patterns of clustered circadian spliceosome components and SFs in SW480 and SW620 cells. Acrophases and amplitudes of the circadian spliceosome components and SFs in SW480 (d) and SW620 (e). Transcripts that show circadian oscillations in both cell lines are written in bold. The components are color-coded according to their protein class/family or their recruitment to the spliceosome complex (lime: recruited at A complex, maroon: recruited at B complex, olive: recruited at B_act complex, navy: recruited at C complex, gray: U11/U12 snRNP, cyan: U1 snRNP, green: 17S U2 snRNP or U2 snRNP associated, dark yellow: U5 snRNP, orange: U4/U6 snRNP, light red: PRP19 complex and PRP19 related, light olive: RES complex, purple: EJC/mRNP, blue: Sm/LSm protein, yellow with border: hnRNP, green with border: SR protein and SR related, red with border: alternative SF, teal with border: linked to splicing and other regulators).