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Malt1-induced cleavage of Regnase-1 in T cells regulates immune activation. Regnase-1 regulates the mRNAs of a set of genes, including c-Rel, Ox40 and Il-2, through cleavage of their 3′ UTRs. TCR stimulation leads to cleavage of Regnase-1 at Arg111 by Malt1, resulting in a ‘brake’ of Regnase-1 function and leading to activation of T cells.
