FIGURE 1.

Anatomical and behavioral results. (A) Patient’s atrophy pattern at the initial evaluation (Eval-1, age 71, left panel) and the second evaluation (Eval-2, age 73, right panel). The image evidences the progression of neurodegeneration from posterior regions (in Eval-1) to frontal and motor regions (in Eval-2), as compared to healthy sociodemographically matched controls (p < 0.001 uncorrected, with an extension of 30 voxels; coordinates are in MNI space). (B) Patient’s fluency performance compared to age-matched norms. Noun fluency was affected in both assessments, whereas action-verb fluency proved impaired only in Eval-2. The asterisk (^∗) indicates significant differences (p < 0.05 and p < 0.001) between the patient’s performance and normative values.