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. 2018 Aug 3;12:243. doi: 10.3389/fncel.2018.00243

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Copyright © 2018 Cheray and Joseph.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histone modifications occurring upon microglia polarization. (A) Post-translational modifications on histone tails that occur in microglia are represented. These covalent modifications are added or removed by histone modifying enzymes often referred as writers and erasers. (B) Positive or negative correlation for the expression levels of these histone modifications or the enzymes regulating those histone marks with the polarization toward so-called “M1” or “M2” microglia phenotypes are reported. Ac, Acetylated; me, methylated.