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B. fragilis ameliorates MTX-induced macrophage alterations. (a) M1 macrophages and (b) M2 macrophages in the MLNs. (c) M1 macrophages and (d) M2 macrophages in the spleen. (A-D, n = 3/group). *P < 0.05 and **P < 0.01 versus blank control. #P < 0.05, ##P < 0.01 and ###P < 0.001 versus metronidazole + MTX.
