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. 2001 Oct 23;98(23):13249–13254. doi: 10.1073/pnas.231473998

Figure 1.

Figure 1

Effect of ICE deficiency and IL-1Ra treatment during acute colitis. Untreated or hyaluronic acid-treated WT, ICE KO, and WT mice injected i.p. with IL-1Ra (100 mg/kg) once daily were fed with 3.5% DSS for 5 days followed by 5 days of regular drinking water. (A) Change in body weight. (B) Diarrhea score. (C) Bleeding score. Each score was assessed daily as described in Materials and Methods. Non-DSS control mice, either ICE KO or WT, are summarized as controls, as no differences among these groups could be detected. Data are mean ± SEM. *, P < 0.05; **, P < 0.01; ***, P <0.001 vs. DSS WT.