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. 2018 Aug 9;37:188. doi: 10.1186/s13046-018-0856-6

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — ATG5 expression correlated positively with TSSC3 expression in osteosarcoma and predicts a favorable prognosis. a Representative images (200× and 400×) of immunohistochemistry (IHC) positive or negative staining for TSSC3, ATG5, and P62 in human osteosarcoma tissues. A mass of yellow or brown color in tumor cells is considered as a positive staining. Scale bars: 50 μm. b Higher IHC scores of ATG5, which symbolized protein expression intensity, was found in patients with TSSC3(+) osteosarcoma compared with that in patients with TSSC3(−) osteosarcoma. c There was no significant correlation between TSSC3 and P62. *P < 0.05. d Kaplan–Meier curves showing that positive expression of TSSC3 is significantly associated with an improved prognosis and longer overall survival (P < 0.05), e while ATG5 and P62 expression is not (P > 0.05). f Kaplan–Meier curve showing that positive expression for both TSSC3 and ATG5 is significantly associated with a favorable prognosis (P < 0.05)