Table 2.
Top 10 genes for degree in PPI network for DEGs between HLCs and PHHs
| Gene | Degree | Top P-value KEGG pathway | Top P-value GOTERM_BP_FAT | Fold change |
|---|---|---|---|---|
| Upregulated DEGs | ||||
| TOP2A | 260 | None | GO:0000278: mitotic cell cycle | 218.0750636 |
| CDK1 | 235 | hsa04110: cell cycle | GO:0000278: mitotic cell cycle | 11.94033162 |
| CCNB1 | 198 | hsa04110: cell cycle | GO:0000278: mitotic cell cycle | 30.20813056 |
| MYC | 196 | hsa04110: cell cycle | GO:0007049: cell cycle | 6.04915656 |
| PCNA | 193 | hsa04110: cell cycle | GO:0000278: mitotic cell cycle | 5.543822244 |
| Downregulated DEGs | ||||
| ALB | 250 | None | GO:0010876: lipid localization | 9.20E-05 |
| ACACB | 151 | hsa01100: metabolic pathways | GO:0006082: organic acid metabolic process | 0.009806799 |
| DECR1 | 138 | None | GO:0006082: organic acid metabolic process | 0.159393422 |
| DPYD | 128 | hsa01100: metabolic pathways | GO:0006082: organic acid metabolic process | 0.015090098 |
| EHHADH | 115 | hsa01100: metabolic pathways | GO:0006082: organic acid metabolic process | 0.020681003 |
DEG differentially expressed gene, GO Gene Ontology, HLC hepatocyte-like cell, PHH primary human hepatocyte, KEGG Kyoto Encyclopedia of Genes and Genomes, PPI protein–protein interaction