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. 2018 Aug 3;9:848. doi: 10.3389/fphar.2018.00848

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Copyright © 2018 Bader, Jügelt, Schultz and Schroeder.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Multi-parametric analysis of cortical neuron network activity. (A) Regime of culture preparation of primary mouse neurons. Smaller images: recording setup and 48 well MEA neurochip (Axion Biosystems). (B) Time scheme of recording and compound addition. (C) Spike raster plots of native cortical activity (control) and cortical activity after acute treatment an excitatory compound illustrating changes in activity patterns. (D) Scheme of two simplified bursts outlining some of the parameters extracted from the recordings in this study. SD = standard deviation. CVtime = coefficient of variation over time.