Figure 5.

Multi-parametric Aβ42 effects are integrated and presented as “NP Effect Score”. Left: NP Effect Score for DMSO and Abeta normalized to “0” and “1”, respectively. 15 best-describing parameters (partly including those showin in Figure 2) were integrated in the Effect Score. Right: NP Effect Score for all test compounds. Starting point is the intrinsic Aβ42 effect (set to 1). DMSO control is stable over time. The 3 h time point represents the time of highest resolution and thus the optimal time point for ranking compound efficacies to rescue Aβ42 effects toward DMSO control conditions. N-DMSO = 18, N-Aβ42 = 75. At 3 h time point: ANOVA with p ≤ 0.033, Dunnett's test with *p ≤ 0.05.