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. 2018 Aug 9;10:108. doi: 10.1186/s13148-018-0541-9

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Characterisation of differentially methylated probes (DMPs) (N = 4133). a Classification of the DMPs into hyper- and hypomethylated probes. b Distribution of the hyper- and hypomethylated probes across different genomic regions. c Hierarchical clustering with 4133 DMPs shows distinctly separate clusters for disease and adjacent normal samples. Normal samples are marked in light green, and disease samples are marked in dark green. d Overlap of DMPs with psoriasis susceptibility regions (PSORS) and non-PSORS. e Distribution of PSORS-overlapping DMPs across various known PSORS loci. Loci significantly enriched (P value ≤ 0.05) in hypergeometric test are marked (*)