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. 2018 Aug 9;16:220. doi: 10.1186/s12967-018-1593-5

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 13 — Identification of hubgenes from the PPI network with the MCODE algorithm. The node color changes gradually from green to red in ascending order according to the log2(foldchange) of genes. The edge size changes gradually from fine to coarse in ascending order according to the combined score between two neighbored genes. a A PPI network of the 172 target genes that exert momentous roles in hepatocellular carcinoma. This network consists of 91 nodes and 131 edges. The node size changes gradually from small to large in ascending order according to the number of neighbored genes per gene. b A PPI network of the 7 hubgenes that extracted from a. This network consists of 7 nodes and 18 edges. PPI protein–protein interaction, MCODE Molecular Complex Detection