Fig. 2.

Area under the receiver operating characteristic (ROC) curve (AUC) for a multivariable logistic regression model of clinically active disease. a Cytokine levels in active and inactive systemic lupus erythematosus (SLE). The bars show the median level and the error bars represent the IQR. Data were compared using the Mann-Whitney U test: *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. After Bonferroni correction, IL-18 was no longer statistically significantly increased in patients with SLE. b The ROC curve is shown for the basic clinical model (blue line) and the same model with the addition of IL-10, IL-21, pentraxin (PTX)-3 and chemokine (C-X-C motif) ligand (CXCL)-10 (four-cytokine model) (red line). The AUC was 0.7312 and 0.9261, respectively (p < 0.001). BLyS B, lymphocyte stimulator; IFNα, interferon alpha; MCP, monocyte chemotactic protein