Table 3.

Smoking status, intensity, burden and BNP levels (log transformed) at Visit 1

Smoking Status	Never Smoker	Former Smoker	Current Smoker
Model		β (95%CI)	β (95%CI)
Model 1	Ref.	0.000 (−0.094, 0.095)	0.218 (0.111, 0.325) †
Model 2	Ref.	0.042 (−0.053, 0.137)	0.182 (0.074, 0.290) †
Model 3	Ref.	0.165 (−0.026, 0.357)	0.329 (0.061, 0.597) *

Smoking Intensity‡	Never Smoker	<10 Cigarettes/day	10–19 Cigarettes/day	≥ 20 Cigarettes/day
Model		β (95%CI)	β (95%CI)	β (95%CI)
Model 1	Ref.	0.101 (−0.086, 0.288)	0.203 (0.038, 0.367) *	0.341 (0.165, 0.516) †
Model 2	Ref.	0.065 (−0.123, 0.252)	0.151 (−0.015, 0.317)	0.298 (0.122, 0.474) †
Model 3	Ref.	0.135 (−0.297, 0.568)	0.321 (−0.098, 0.741)	0.711 (0.206, 1.215) †

Smoking Burden‡	Never Smoker	< 7.5 Pack-years	7.5-15 Pack-years	15-30 Pack-years	≥ 30 Pack-years
Model		β (95%CI)	β (95%CI)	β (95%CI)	β (95%CI)
Model 1	Ref.	0.036 (−0.132, 0.204)	0.083 (−0.061, 0.228)	0.075 (−0.050, 0.200)	0.119 (−0.002, 0.240)
Model 2	Ref.	0.030 (−0.139, 0.199)	0.104 (−0.040, 0.248)	0.069 (−0.055, 0.193)	0.139 (0.018, 0.260) *
Model 3	Ref.	−0.001 (−0.385, 0.384)	0.112 (−0.216, 0.441)	0.213 (−0.056, 0.482)	0.375 (0.124, 0.626) †

body mass index, systolic blood pressure, anti-hypertensive medication use, diabetes and estimated glomerular filtration rate. Model 3: adjusted for Model 2, but including mean systolic ambulatory blood pressure instead of office systolic blood pressure

^*:p<0.05,

^†:p<0.01.

^‡Smoking intensity analyses include only never smoker and current smoker. Smoking burden analyses include never smoker and ever smoker.