Table 3.
Potential high binding (IC50 < 50 nM) CD8+ T-cell, CD4+ T-cell, and B-cell epitopes in Plasmodium falciparum reticulocyte–binding homologue-5
| Allele | Predicted peptide | IC50 (nM) | MHC restriction | Number of polymorphic sites |
|---|---|---|---|---|
| T-cell epitopes | ||||
| Class I | ||||
| HLA-A*23:01 | KYLFIPSHNSFI | 9.08 | 0 | |
| HLA-A*30:01 | KIKLNIWRTFQK | 16.15 | 0 | |
| HLA-B*35:01 | YTFLDYYKHLSY | 19.23 | 0 | |
| HLA-B*35:01 | FVIIPHYTFLDY | 22.85 | 0 | |
| HLA-A*30:01 | GIRYHYDEYIHK | 24.39 | 0 | |
| HLA-A*02:01 | ILQEKEGHLDFV | 27.43 | 0 | |
| HLA-A*23:01 | TYGKCIAVDAFI | 38.75 | 1 | |
| HLA-A*30:01 | KTNNAKDHSTYI | 44.27 | 0 | |
| Class II | ||||
| DRB1_1304 | KLILSVKSKNLN | 33.82 | 1 | |
| SYIYIDTIKFIH | 35.44 | 2 | ||
| HKLILSVKSKNL | 36.13 | 1 | ||
| TNILQQSELLLT | 40.87 | 0 | ||
| GSYIYIDTIKFI | 43.09 | 2 | ||
| IKFIHKEMKHIF | 43.28 | 1 | ||
| SELLLTNLNKKM | 44.77 | 0 | ||
| TKIINDKTKIIQ | 45.48 | 0 | ||
| DRB1_0701 | KYLFIPSHNSFI | 32.95 | 0 | |
| YLFIPSHNSFIK | 39.41 | 0 | ||
| KLILSVKSKNLN | 40.14 | 1 | ||
| HKLILSVKSKNL | 44.98 | 1 | ||
| SNYNIANSIDIL | 49.01 | 0 | ||
| DRB1_1101 | YIHKLILSVKSK | 29.07 | 1 | |
| HKLILSVKSKNL | 30.62 | 1 | ||
| KLILSVKSKNLN | 33.20 | 1 | ||
| LKYLFIPSHNSF | 35.97 | 0 | ||
| EYIHKLILSVKS | 34.24 | 1 | ||
| KYLFIPSHNSFI | 41.07 | 0 | ||
| IHKLILSVKSKN | 41.24 | 1 | ||
| IKFIHKEMKHIF | 44.58 | 1 | ||
| DRB1_0120 | KYLFIPSHNSFI | 8.430 | 0 | |
| KLILSVKSKNLN | 8.80 | 1 | ||
| LKYLFIPSHNSF | 9.77 | 0 | ||
| HKLILSVKSKNL | 11.39 | 0 | ||
| LILSVKSKNLNK | 11.66 | 1 | ||
| GLKYLFIPSHNS | 12.49 | 0 | ||
| YLFIPSHNSFIK | 12.23 | 0 | ||
| B-cell epitopes | ||||
| KKYSVFNQINDG | 1 | |||
| DSYRYDISEEID | 0 | |||
| EIDNDKENIKTN | 1 | |||