Table 1.
Comparison of methicillin-susceptible (MSSA) and methicillin-resistant S. aureus (MRSA) bacteremia cases, Sa Kaeo and Nakhon Phanom provinces, Thailand 2006–2014
| Characteristic | MSSA* | MRSA* | Total* | P value† |
|---|---|---|---|---|
| Age, n (%) | ||||
| Neonate (0–28 days) | 57 (7.0) | 6 (6.7) | 63 (7.0) | 0.06 |
| 29 days–14 years | 90 (11) | 3 (3.3) | 93 (10) | |
| 15–49 years | 246 (30) | 22 (24) | 268 (29) | |
| 50–69 years | 275 (34) | 36 (40) | 311 (34) | |
| ≥ 70 years | 153 (19) | 23 (26) | 176 (19) | |
| Sa Kaeo Province, n (%) | 376 (46) | 60 (67) | 436 (48) | < 0.001 |
| Provincial Hospital, n (%) | 514 (63) | 71 (79) | 585 (64) | 0.01 |
| Community-onset, n (%) | 681/770 (88) | 55/77 (71) | 736/847 (87) | < 0.001 |
| Current antibiotic exposure, n (%) | 60/773 (7.8) | 25/85 (29) | 85/858 (9.9) | < 0.001 |
| Antibiotic resistance,‡ n (%) | ||||
| Erythromycin | 39/785 (5.0) | 73/87 (84) | 112/872 (13) | < 0.001 |
| Gentamicin | 0/505 (0) | 33/40 (83) | 33/545 (6.1) | < 0.001 |
| Clindamycin | 28/800 (3.5) | 66/88 (75) | 94/888 (11) | < 0.001 |
| Cotrimoxazole | 7/797 (0.9) | 54/83 (65) | 61/880 (6.9) | < 0.001 |
| Fosfomycin | 4/361 (1.1) | 21/65 (33) | 25/426 (5.9) | < 0.001 |
| Vancomycin | – | 0/35 | – | – |
| Resistance to at least two antibiotics other than methicillin | 24 (2.9) | 72 (80) | 96 (11) | < 0.001 |
*
MSSA denominator 821, MRSA denominator 90, and total 911 unless missing data, and then a different denominator noted.
†
χ2 or Fisher exact testing, as appropriate comparing MSSA vs. MRSA.
‡
Antibiotic testing algorithm differed over time and between provinces. Disk diffusion method was used for all antibiotics except for vancomycin, for which E-test was used.