Table 3.
In vitro activities of antimalarial (IC50, nM) in 50% plasma against Plasmodium falciparum isolates with different drug susceptibilities
| Drug | D6 | MRA1239 | MRA1240 |
|---|---|---|---|
| Artemisinin | 13.2 ± 2.6 | 8.5 ± 2.8 | 41.6 ± 11.9 |
| Piperaquine | 33.2 ± 5.5 | 104.2 ± 12.1 | 131.2 ± 28.9 |
| Artesunate | 3.3 ± 1.1 | ND± | ND± |
| Dihydroartemisinin | 2.5 ± 0.1 | 2.4 ± 1.2 | 9.0 ± 1.9 |
| Amodiaquine | 8.54 ± 0.03 | ND± | ND± |
| Desethylamodiaquine | 8.2 ± 0.3 | 14.8 ± 6.8 | 34.8 ± 8.6 |
ND = not determined. Mean ± SD. IC50 data based on at least two independent experiments.