Table 4.
Comparison of the inhibitory dilution (ID50: number of dilutions of plasma sample that produces a 50% inhibition of hypoxanthine uptake into malaria parasites compared with drug-free plasma control samples) of plasma samples obtained from six healthy Vietnamese volunteers who were administered either a 3-day regimen of ARS–AQ (Coarsucam) or ARN–PPQ (Artequick) against the ARN-sensitive MRA1239 and the ARN-resistant MRA1240 Plasmodium falciparum lines
| Time (hour) | MRA1239 ID50 (fold) ARS–AQ | MRA1239 ID50 (fold) ARN–PPQ | Difference ratio* (P value) |
|---|---|---|---|
| Mean ± SEM | Mean ± SEM | ||
| D0 | 0 ± 0 | 0 ± 0 | – |
| D2—1.5 hours | 1,117.3 ± 265.5 | 53.7 ± 14.7 | 20.8 (0.0428) |
| D2—4.0 hours | 360.8 ± 98.5 | 103.1 ± 19.2 | 3.5 (0.0417) |
| D3—24 hours | 169.4 ± 15.5 | 20.0 ± 5.6 | 8.5 (0.0003) |
| Time (hours) | MRA1240 ID50 (fold) ARS–AQ | MRA1240 ID50 (fold) ARN–PPQ | Difference ratio* (P value) |
|---|---|---|---|
| Mean ± SEM | Mean ± SEM | ||
| D0 | 0 ± 0 | 0 ± 0 | – |
| D2—1.5 hours | 252.9 ± 57.2 | 46.8 ± 11.1 | 5.4 (0.0206) |
| D2—4.0 hours | 83.6 ± 17.1 | 96.4 ± 18.0 | 0.9 (0.5891) |
| D3—24 hours | 9.3 ± 0.8 | 9.6 ± 2.4 | 1.0 (0.2510) |
AQ = amodiaquine; ARN = artemisinin; ARS = artesunate; PPQ = piperaquine.
*
Difference: ratio of ID50 values for ARS-AQ/ARN-PPQ against MRA1239 and MRA1240.