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Model for the pathway by which As(III) activates Hog1. As(III) is metabolized by the methyltransferase Mtq2:Trm112 to MAs(III), which inhibits the Ptp2 and Ptp3 tyrosine phosphatases that modulate the phosphorylation state of Hog1. This results in activation of Hog1 by shifting the balance toward the phosphorylated state. As(V) activates Hog1 through a different pathway that involves the activation of Pbs2 (dashed arrow).
