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. Author manuscript; available in PMC: 2018 Aug 10.
Published in final edited form as: Am J Transplant. 2017 Jan 3;17(5):1334–1345. doi: 10.1111/ajt.14081

Figure 1. Conceptual Model of Disablement.

Figure 1

Proposed by Nagi(43), the pathway begins with a disease process that causes organ pathology. As this pathology becomes clinically relevant, organ dysfunction emerges, termed impairment. Impairment, in turn, leads to reductions in actions, termed functional limitations. Functional limitations may then lead to disability, defined as difficulty performing activities in daily life. Disability is an upstream precursor to and determinant of both health-related quality of life (HRQL) and mortality.