Table 1.
Demographics and baseline characteristics among 211 transplanted study participants
| Overall | COPD | PAH | CF | PF | |
|---|---|---|---|---|---|
| n=211 | n=36 | n=8 | n=19 | n=148 | |
| Age (years) | 58 (48, 64) | 63 (56, 65) | 47 (38, 52) | 28 (24, 40) | 60 (52, 65) |
| Age group | |||||
| 18–49 | 56 (27%) | 3 (8%) | 6 (75%) | 19 (100%) | 28 (19%) |
| 50–64 | 103 (49%) | 20 (56%) | 2 (25%) | 0 (0%) | 81 (55%) |
| 65+ | 52 (25%) | 13 (36%) | 0 (0%) | 0 (0%) | 39 (26%) |
| Female | 97 (46%) | 20 (56%) | 5 (63%) | 11 (58%) | 61 (41%) |
| BMI (kg/m2) | 25.5 (22.1, 28.5) | 24.1 (21.2, 27.6) | 25.2 (20.8, 27.7) | 19.1 (18.3, 21.1) | 26.5 (23.4, 29.4) |
| Hospitalized at transplant** | 68 (33%) | 7 (19%) | 1 (13%) | 7 (39%) | 53 (36%) |
| Intubated at transplant | 22 (11%) | 2 (6%) | 0 (0%) | 4 (22%) | 16 (11%) |
| ECMO at transplant | 19 (9%) | 1 (3%) | 1 (13%) | 2 (11%) | 15 (10%) |
| FEV1 | 1.31 (0.86, 1.86) | 0.61 (0.42, 1.05) | 1.87 (1.05, 2.49) | 0.78 (0.54, 0.95) | 1.61 (1.11, 2.03) |
| FEV1 % Predicted | 45 (28, 61) | 24 (15.5, 42) | 54 (39, 66) | 23 (16, 28) | 51 (39, 64) |
| 6MWD (m) | 254 (151, 365) | 247 (139, 320) | 308 (173, 529) | 348 (171, 472) | 247 (153, 366) |
| LAS | 45.2 (38.1, 64.4) | 35.9 (33.0, 39.8) | 38.6 (34.7, 49.6) | 40.3 (38.5, 48.6) | 52.4 (40.8, 70.4) |
| SF12 PCS | 22.9 (16.5, 26.8) | 22.0 (18.4, 28.3) | 25.3 (22.8, 31.1) | 24.1 (14.8, 25.9) | 22.9 (16.1, 25.7) |
| SF12 MCS | 50.6 (40.6, 56.7) | 52.6 (47.3, 58.5) | 48.8 (28.9, 62.3) | 44.1 (37.8, 52.6) | 50.9 (40.6, 57.1) |
| AQ20-R | 6 (4, 9) | 6 (3, 11) | 7 (2, 12) | 5 (4, 7) | 7 (4, 9) |
| EQ5D | 0.69 (0.57, 0.78) | 0.69 (0.59, 0.79) | 0.79 (0.60, 0.82) | 0.60 (0.44, 0.78) | 0.69 (0.55, 0.78) |
| VAS | 40 (25, 60) | 50 (30, 65) | 45 (40, 70) | 29 (20, 30) | 40 (25, 60) |
Data presented as n (%) or median (IQR).
Diagnosis categories used for calculation of the Lung Allocation score.
Subject was hospitalized at the time of receiving a donor offer for transplant. COPD = Chronic Obstructive Pulmonary Disease; PAH = Pulmonary Arterial Hypertension; CF = Cystic Fibrosis; PF = Pulmonary Fibrosis; BMI = Body Mass Index; 6MWD = six-minute walk distance; ECMO = extra-corporeal membrane oxygenationFEV1 = forced expiratory capacity in 1 second; LAS = Lung Allocation Score; SF12 PCS = Medical Outcomes Study Short Form 12 Physical Component Summary scale; SF12 MCS = Medical Outcomes Study Short Form 12 Mental Component Summary scale; AQ20-R = Airway Questionairre 20 - revised; EQ5D = Euroqol 5D; VAS = Euroqol Visual Analog Scale