Table 1. Functional annotations of Suit2-007 PDAC cells, re-isolated from pancreas, liver and lung.
| Functional annotations, pancreas environmenta | p-Valueb | Predicted activationc | Activation z-scored | Number of genese |
|---|---|---|---|---|
| Cell movement | 1,56E-11 | increased | 2,199 | (178/326) |
| Cell signaling & interaction (interaction of tumor cells) | 2,40E-10 | increased | 2,559 | (60/109). |
| Gene expression | 6,19E-09 | increased | 2,572 | (143/341) |
| Cellular assembly, DNA replication, recombination & repair (nuclear foci formation) | 3,33E-05 | increased | 3,142 | (6/24) |
| Cell death & survival (cell death of squamous cell carcinoma) | 4,18E-05 | increased | 2,414 | (12/24) |
| Cell death & survival (viability of ovarian cancer cells) | 1,69E-04 | increased | 2,215 | (7/17) |
| Cancer, organismal injury & abnormalities | 2,18E-07 | decreased | −2,198 | (45/59) |
| Infectious diseases | 1,44E-12 | decreased | −2,198 | (156/362) |
| Cellular assembly, DNA replication, recombination, and repair (chromosomes alignment) | 6,68E-06 | decreased | −2,976 | (8/12) |
| Cell cycle (M phase of tumor cell lines) | 6,89E-05 | decreased | −2,240 | (14/29) |
| Cell cycle (progression of cervical cancer cells) | 6,93E-05 | decreased | −2,138 | (9/29) |
| DNA replication, recombination, and repair | 9,29E-05 | decreased | −2,135 | (11/30) |
| Cell cycle (interphase of cancer cells) | 9,50E-05 | decreased | −2,343 | (18/20) |
| Cellular development | 1,05E-04 | decreased | −2,678 | (6/10) |
| Cell cycle (re-entry into interphase) | 1,09E-04 | decreased | −2,121 | (15/36) |
| Functional annotations, liver environmenta | ||||
| Cell signaling & interaction (interaction of tumor cells) | 1,23E-13 | increased | 2,191 | (28/77) |
| Cellular movement, immune cell trafficking (leukocyte migration) | 3,58E-05 | increased | 3,039 | (23/49) |
| Inflammatory response | 5,19E-06 | increased | 2,423 | (25/49) |
| Cell signaling & interaction (activation of tumor cells) | 3,91E-05 | increased | 2,011 | (17/53) |
| Cellular movement (homing of cells) | 1,84E-04 | increased | 2,998 | (23/48) |
| Cellular growth & proliferation (colony formation) | 5,90E-04 | increased | 2,044 | (4/15) |
| Neurological, skeletal & muscular disorders (neuromuscular disease) | 5,54E-05 | increased | 2,449 | (48/106) |
| Neurological disease (progressive motor neuropathy) | 3,02E-07 | increased | 2,449 | (36/81) |
| Cell death & survival (cell death) | 3,68E-16 | decreased | −2,162 | (103/306) |
| Functional annotations, lung environmenta | ||||
| Cellular growth, development, &proliferation | 1,06E-13 | increased | 2,979 | (19/157) |
| Cell death & survival (tumor cells viability) | 6,69E-07 | increased | 2,657 | (29/77) |
| Organismal development | 1,80E-04 | increased | 2,461 | (19/19) |
| Gene expression (transactivation) | 8,91E-07 | increased | 2,607 | (20/46) |
| Infectious diseases (viral infection) | 1,40E-04 | increased | 2,953 | (41/116) |
| Lipid metabolism & molecular transport | 1,54E-03 | decreased | −2,176 | (9/9) |
| Cellular movement (invasion of tumor cells) | 1,03E-03 | decreased | −2,157 | (10/10) |
Functional annotations represent predicted biological functions of gene clusters derived from Ingenuity Pathway Analysis
p-Value is the calculated probability derived from individual gene cluster in a defined annotation for the respective gene group.
Predicted activation is the overall activation state (increased or decreased) of the functional annotation for respective genes in a given gene cluster
Activation Z-score is a defined quantity, which determines whether a biological function has significantly more “increased” predictions than “decreased” predictions (Z > 0) or vice versa (Z < 0).
Number of genes represent selected genes based on significant modulation of expression versus the total number of genes for respective functional annotation