Table 7.

Relative change in target biomarker levels associated with IQR changes in air pollutant levels

Pollutant	Biomarker	Ratio (95%CI)
CO	IL-12	1.077 (1.018, 1.139)*
	IL-13	1.046 (1.009, 1.086)*
	IL-5	1.022 (0.998, 1.047)+
	IL-6	1.042 (1.009, 1.077)*
	IL-7	1.043 (1.007, 1.080)*
	IL-8	1.016 (1.001, 1.032)*
	L Selectin	0.966 (0.934, 1.000)*
	ET 1–21 (saliva)	0.966 (0.933, 1.000)*
	ET 1–31 (saliva)	0.962 (0.920, 1.007)+
	ET 3 (saliva)	1.011 (0.975, 1.047)+
NO	GMCSF	0.910 (0.818, 1.012)+
	IL-4	0.859 (0.718, 1.027)+
	IL-8	0.906 (0.845, 0.972)*
NO2	ET 1–21 (saliva)	1.090 (0.904, 1.314)+
NOX	IL-8	0.915 (0.847, 0.989)*
O3	Adipsin	0.669 (0.433, 1.034)+
	GMCSF	1.170 (0.979, 1.398)+
	IL-2	1.476 (1.120, 1.945)*
	L Selectin	0.794 (0.630, 1.000)+
	Big ET-1 (plasma)	1.417 (1.024, 1.962)*
	Big ET-1 (saliva)	0.616 (0.363, 1.046)+
	ET 1–21 (saliva)	0.776 (0.609, 0.988)*
	SAP	0.672 (0.445, 1.013)+
	TNF-α	1.143 (1.006, 1.299)*
	vWF	0.562 (0.328, 0.963)*
SO2	Haptoglobin	1.080 (0.988, 1.182)+
	PF4	0.914 (0.829, 1.007)+
	ET 1–21 (plasma)	1.401 (1.056, 1.858)*
	vWF	1.265 (0.953, 1.679)+
UFP	A2M	0.543 (0.348, 0.848)*
	Adipsin	0.244 (0.095, 0.627)*
	AGP	0.362 (0.209, 0.626)*
	Fibrinogen	0.504 (0.309, 0.823)*
	Haptoglobin	0.548 (0.359, 0.837)*
	L Selectin	0.684 (0.495, 0.947)*
	PF4	0.464 (0.287, 0.750)*
	ET 1–21 (plasma)	4.405 (1.143, 16.973)*
PM2.5	IL-4	0.837 (0.700, 1.000)+
	ET 1–21 (saliva)	1.166 (1.001, 1.344)*
	ET 1–31 (saliva)	1.195 (0.998, 1.430)+
	vWF	1.373 (0.985, 1.912)+

*p < 0.05; +p < 0.1(not significant, trend only)

Covariates: Treatment period, carry over, Age, sex, BMI, atmospheric pressure, temperature and relative humidity