Table 2.

Prevalence and frequency of SNPs at the Pfdfhr and Pfdhps genes

Codon	SNPs	Prevalence			Frequency
		Evaluable sample (N)	Number with specific SNP (n)	% (n/N × 100)	Evaluable sample (N)	Number with specific SNP (n)	% (n/N × 100)
Pfdhfr
50/51	CN	142	36	25.5	136	33	24.3
	CI	142	106	75.5	136	103	75.7
59	C	146	24	16.4	140	21	15.0
	R	146	122	83.6	140	119	85.0
108	S	139	17	12.2	139	17	12.2
	N	139	122	87.8	139	122	87.8
	T	0		0
164	I	132	132	100.0	132	132	100.0
	L	0		0
Pfdhps
436/437	AA	147	3	2.0	141	3	2.1
	AG		95	64.6		95	67.4
	SA		3	2.0		1	0.7
	SG		45	30.6		41	29.1
	FA		1	0.7		1	0.7
540	K	143	142	99.3	141	141	100.0
	E		1	0.7	0
581	A	152	147	96.7	150	146	97.3
	G		5	3.3		4	2.7
613	A	148	138	93.2	146	137	93.8
	S		10	6.8		9	6.2
Pfdhfr and Pfdhps haplotypes*
Pfdhfr† (N = 126)
CIRNI			97	77
CNCSI			9	7.1
Pfhdps (N = 130)
AGKAA			80	61.5
SGKAA			39	30
AGKAS			6	4.6
AGKGS			1	0.8
AAKAA			3	2.3
SAKAA			1	0.8
Pfdhfr/ (N = 81)
CIRNI/AGKAA (quadruple mutation)			42	51.9
CIRNI/SGKAA (quadruple mutation)			33	40.7
CIRNI/AGKAS (quintuple mutation)			5	6.2
CIRNI/AGKGS (sextuple mutation)			1	1.2

SNPs = single nucleotide polymorphisms.

^*Only frequencies are reported for haplotypes and N is evaluable samples whereas n is the number of haplotypes.

^†The Pfdhfr double mutations (CNRNI + CICNI + CIRSI) collectively constituted 15.9%.