Table 1.

Controlled human malaria infection studies used in this analysis

	Year	Trial registration number	Number of volunteers	Sporozoite prevalence (% mosquitoes infected)	Sporozoite intensity (mean number of sporozoites per mosquito)
Study 1	2007	NCT00442377	5	80	31,500
Study 2	2008	NCT00509158	18	100	72,800
Study 3	2009	NCT00757887	5	96.5	88,000
Study 4	2010	NCT01002833	4	100	69,000
Study 5	2011	NCT01218893	5	100	79,500
Study 6	2012	NCT01422954	4	100	98,250
Study 7	2012	NCT01627951	5	100	101,250
Study 8	2012	NCT01728701	5	93.8	75,800
Study 9	2012	NCT01728701	4	100	98,000
Study 10	2015	NCT02080026	5	100	74,000
Study 11	2015	NCT02098590	2	90	26,500
Study 12	2015	NCT02098590	3	100	44,300
Study 13	2016	NCT02692963	10	100	160,500
Total			75