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. 2018 Jul 27;9(1):1019–1035. doi: 10.1080/21505594.2018.1475797

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© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Suggestive identification and measurement of fungal 5D2-IsoP in wild type and eicosanoid mutant strains. Upper left, LC/MS analysis of cell supernatant after growing C. parapsilosis wild type strain in presence of 100 μM arachidonic acid in PBS. Blue trace shows the elution of an authentic LXA₄ standard (1 ng/mL) in the transition m/z 351-> 115. Red trace shows the elution of an overlapping signal in a representative C. parapsilosis sample. (Upper right) MS/MS spectrum of the signal co-eluting with LXA₄ and chemical structure of the candidate molecule 5D2-IsoP. Middle MS³ spectra of m/z 271 (left) and m/z 217 (right). Lower panel, CPAR2_800020Δ/Δ showed a significant reduction in 5D2-IsoP production, although 5D2-IsoP levels also decreased in CPAR2_603600Δ/Δ and CPAR2_807710Δ/Δ strains.