Fig. 1.

S1P induces fHASC migration mostly via S1PR1, and moderately through SP1R3 and S1PR4. A) fHASC migration in response to three different S1P concentrations. Data are mean ± S.D. from 3 independent experiments. **P < 0.01, (ANOVA and Bonferroni multiple comparison test). B) S1PRs mRNA expression levels in fHASCs. Data (mean ± S.D.) are presented as normalized transcripts expression in the samples, relative to transcript expression of S1PR5 (in which fold change = 1; dotted line); one experiment representative of two. C) Effect of S1PR1–5 silencing on S1P-induced fHASC migration. Data are means ± S.D. from three independent experiments. ** P < 0.01, ANOVA followed by Bonferroni multiple comparison test.