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. Author manuscript; available in PMC: 2018 Aug 10.
Published in final edited form as: Oncogene. 2016 Apr 4;35(40):5295–5303. doi: 10.1038/onc.2016.70

Figure 6. Autophagy inhibition synergizes with vemurafenib to prevent melanoma growth in vivo.

Figure 6.

(a) YUKSI BRAFmut melanoma cells were injected into mice and allowed to form palpable tumors (4–5 mm) followed by indicated drug treatments (see full Materials and methods). (b) Top—Images of representative tumors from mice treated with control, vem, CQ or vem+CQ; scale bar 5 mm. Bottom—Data represent mean tumor volume±s.e.m. (n=5 mice per treatment group; *P<0.05). (c) Immunohistochemical staining showing levels of pAMPK, pERK1/2, ERK1/2 and LC3B puncta in tumors from vemurafenib- vs control-treated mice; scale bar 100 μm.