Table 3.
Total and regional body composition measures
| Variable | Unadjusted Mean ± SD |
Adjusted* LSMean ± SE |
||||
|---|---|---|---|---|---|---|
| HFpEF | HC | p-Value | HFpEF | HC | p-Value | |
| DEXA | ||||||
| Total Mass (kg) | 102.4 ± 14.2 | 75.7 ± 16.3 | <0.001 | 94.4 ± 0.6 | 88.0 ± 0.8 | <0.001 |
| Total Fat Mass (kg) | 46.7 ± 10.2 | 24.1 ± 9.4 | <0.001 | 41.0 ± 0.7 | 32.9 ± 0.9 | <0.001 |
| Total Percent Fat | 45.5 ± 6.4 | 31.5 ± 8.5 | <0.001 | 42.8 ± 0.6 | 35.6 ± 0.8 | <0.001 |
| Total Lean Mass (kg) | 53.3 ± 9.1 | 49.3 ± 11.0 | 0.016 | 51.1 ± 0.4 | 52.8 ± 0.6 | 0.041 |
| Total Percent Lean | 52.2 ± 6.3 | 65.5 ± 8.2 | <0.001 | 54.7 ± 0.6 | 61.6 ± 0.8 | <0.001 |
| MRI | ||||||
| Abdominal SC fat (cm2) | 377.8 ± 145.2 | 147.7 ± 84.5 | <0.001 | 312.9 ± 12.8 | 236.9 ± 15.9 | 0.002 |
| Intra-peritoneal fat (cm2) | 116.4 ± 61.5 | 68.8 ± 60.4 | <0.001 | 110.0 ± 6.4 | 77.7 ± 8.0 | 0.007 |
| Retroperitoneal fat (cm2) | 94.4 ± 51.3 | 47.3 ± 35.0 | <0.001 | 95.8 ± 4.1 | 45.4 ± 5.1 | <0.001 |
| Intra-abdominal fat (cm2) | 210.8 ± 107.9 | 116.1 ± 90.0 | <0.001 | 205.7 ± 9.7 | 123.1 ± 12.1 | <0.001 |
| Abdominal SC fat/Intra-abdominal fat ratio | 2.34 ± 1.73 | 1.91 ± 1.31 | 0.10 | 1.94 ± 0.18 | 2.46 ± 0.22 | 0.11 |
| Total thigh area (cm2) | 316.8 ± 80.4 | 205.3 ± 47.3 | <0.001 | 277.0 ± 5.6 | 270.7 ± 7.7 | 0.56 |
| Thigh SC fat (cm2) | 165.2 ± 74.8 | 73.8 ± 41.9 | <0.001 | 132.9 ± 5.4 | 126.7 ± 7.5 | 0.55 |
| TC area (cm2) | 151.6 ± 28.7 | 131.5 ± 32.1 | <0.001 | 144.1 ± 2.1 | 143.9 ± 3.0 | 0.96 |
| Femur (cm2) | 4.3 ± 0.7 | 5.9 ± 1.0 | <0.001 | 4.2 ± 0.1 | 6.1 ± 0.1 | <0.001 |
| Thigh IMF (cm2) | 25.9 ± 9.2 | 14.4 ± 5.9 | <0.001 | 23.2 ± 0.9 | 18.9 ± 1.2 | 0.014 |
| Thigh IMF/TC (%) | 17.1 ± 5.2 | 11.3 ± 4.8 | <0.001 | 16.2 ± 0.6 | 12.9 ± 0.8 | 0.003 |
| Thigh SM (cm2) | 121.5 ± 25.7 | 111.2 ± 30.5 | 0.029 | 116.8 ± 2.0 | 118.9 ± 2.8 | 0.58 |
| Thigh SM/TC (%) | 80.0 ± 5.1 | 84.0 ± 5.0 | <0.001 | 80.9 ± 0.6 | 82.6 ± 0.8 | 0.11 |
| Thigh IMF/SM ratio | 0.22 ± 0.08 | 0.14 ± 0.07 | <0.001 | 0.21 ± 0.01 | 0.16 ± 0.01 | 0.009 |
| Paracardial fat (cm3) | 63.1 ± 39.6 | 53.9 ± 36.7 | 0.19 | 63.6 ± 4.1 | 53.1 ± 5.5 | 0.18 |
| Epicardial fat (cm3) | 36.0 ± 17.7 | 54.9 ± 20.6 | <0.001 | 36.3 ± 2.3 | 54.5 ± 3.0 | <0.001 |
| Pericardial fat (cm3) | 99.0 ± 53.0 | 108.8 ± 52.9 | 0.31 | 99.8 ± 5.6 | 107.6 ± 7.6 | 0.48 |
Raw data are presented as mean ± SD;
*
Adjusted for age, race, gender, and body surface area and presented as least square means ± standard error; Intra-abdominal fat = Intra-peritoneal + Retroperitoneal fat; SC fat = Subcutaneous Fat; TC Area = Thigh Compartment Area; SM = Skeletal Muscle; IMF = Intermuscular Fat; TC area = SM + IMF + Femur. Total thigh area = TC Area + Thigh SC fat. Pericardial fat = Paracardial fat + Epicardial fat.