Fig. 5.

Constructing and implementing a parameter estimation algorithm for the PK model based on experimental MSOT data. The PK algorithm required two sets of data input and displayed in a scatter plot where (A) represents the AIF and (B) represents the experimental MSOT quantification data for HS680 in the tumor. The algorithm takes the AIF and experimental data in Eq. (6) and estimates the compartment model rate parameter values for the experimental data. (C) Once the optimal parameter values were determined, the PK model curve was overlaid on top of the experimental MSOT quantification data points. (D) The rate parameter values were charted in the table with R = 0.9945. The curve represents the best-fit curve of the 2-compartment PK model with the optimal rate parameters.