Table 2.
Transcripts showing strong differential expression in sciatic nerve
| Gene symbol | Gene name | Sciatic RPKM | DRG RPKM | Fold sciatic enriched |
|---|---|---|---|---|
| Myelin | ||||
| Mpz | Myelin protein zero | 20036.3 | 3487.6 | 5.7 |
| Pmp22 | Peripheral myelin protein 22 | 10888.9 | 1541.4 | 7.1 |
| Mbp | Myelin basic protein | 4215.8 | 689.5 | 6.1 |
| Pmp2 | Peripheral myelin protein 2 | 1715.5 | 259.5 | 6.6 |
| Mal | Mal, T-cell differentiation protein | 1070.3 | 134.2 | 8.0 |
| Prx | Periaxin | 675.8 | 113.5 | 5.9 |
| Ncmap | Noncompact myelin associated protein | 645.7 | 121.4 | 5.3 |
| Ugt8 | UDP glycosyltransferase 8 | 408.5 | 59.1 | 6.9 |
| Cnp | 2′,3′-cyclic nucleotide 3′ phosphodiesterase | 251.3 | 72.6 | 3.5 |
| Cldn19 | Claudin 19 | 223.6 | 38.2 | 5.8 |
| Pllp | Plasma membrane proteolipid (plasmolipin) | 205.7 | 34.1 | 6.0 |
| Cldn1 | Claudin 1 | 90.4 | 7.4 | 12.1 |
| Emp2 | Epithelial membrane protein 2 | 84.7 | 14.2 | 5.9 |
| Emp1 | Epithelial membrane protein 1 | 79.3 | 11.7 | 6.7 |
| Cldn5 | Claudin 5 | 52.8 | 17.4 | 3.0 |
| Tjp1 | Tight junction protein 1 | 40.4 | 12.6 | 3.2 |
| Cldn22 | Claudin 22 | 11.0 | 0.4 | 22.2 |
| ECM proteins | ||||
| Vim | Vimentin | 1891.6 | 457.1 | 4.1 |
| Dcn | Decorin | 1500.6 | 200.2 | 7.5 |
| Col3a1 | Collagen, type III, alpha 1 | 1090.5 | 86.3 | 12.6 |
| Collai | Collagen, type I, alpha 1 | 964.6 | 74.6 | 12.9 |
| Mgp | Matrix Gla protein | 607.6 | 175.2 | 3.5 |
| Tpm4 | Tropomyosin 4 | 362.7 | 85.2 | 4.3 |
| Lum | Lumican | 217.4 | 58.8 | 3.7 |
| Gpc3 | Glypican 3 | 148.5 | 15.4 | 9.6 |
| Acta2 | Smooth muscle aortic alpha-actin | 142.6 | 20.2 | 7.0 |
| Col6a1 | Collagen, type VI, alpha 1 | 122.0 | 15.5 | 7.8 |
| Col4a1 | Collagen, type IV, alpha 1 | 119.3 | 32.9 | 3.6 |
| Pcolce | Procollagen C-endopeptidase enhancer | 117.1 | 14.2 | 8.2 |
| Col6a2 | Collagen, type VI, alpha 2 | 112.4 | 16.6 | 6.7 |
| Col5a2 | Collagen, type V, alpha 2 | 87.1 | 17.0 | 5.1 |
| Aebp1 | AE-binding protein 1 | 71.3 | 10.2 | 6.9 |
| Col14a1 | Collagen, type XIV, alpha 1 | 61.2 | 13.2 | 4.6 |
| Col5a1 | Collagen, type V, alpha 1 | 41.9 | 13.3 | 3.1 |
| Cpxm2 | Carboxypeptidase X2 | 37.9 | 5.5 | 6.8 |
| Col24a1 | Collagen, type XXIV, alpha 1 | 23.0 | 6.0 | 3.8 |
| Col6a3 | Collagen, type VI, alpha 3 | 16.5 | 4.4 | 3.7 |
| Colec12 | Collectin sub-family member 12 | 13.4 | 2.7 | 4.8 |
| Col9a1 | Collagen, type IX, alpha 1 | 10.7 | 0.7 | 13.5 |
| Cpxm1 | Carboxypeptidase X1 | 10.3 | 3.2 | 3.2 |
| Col11a1 | Collagen, type XI, alpha 1 | 7.9 | 1.8 | 4.2 |
| Col4a5 | Collagen, type IV, alpha 5 | 5.3 | 1.2 | 4.2 |
| Col1a2 | Collagen, type I, alpha 2 | 3.4 | 0.6 | 5.0 |
| Processing enzymes | ||||
| Pam | Peptidylglycine alpha-amidating monooxygenase | 209.3 | 56.7 | 3.7 |
| Maob | Monoamine oxidase B | 167.4 | 22.0 | 7.6 |
| Aspa | Aspartoacylase | 98.1 | 22.2 | 4.4 |
| Padi2 | Peptidyl arginine deiminase, type II | 31.8 | 6.8 | 4.6 |
| Ace | Angiotensin converting enzyme | 25.8 | 2.4 | 10.4 |
| Pcsk6 | Proprotein convertase subtilisin/kexin type 6 | 20.0 | 4.6 | 4.3 |
| Cpa3 | Carboxypeptidase A3 | 17.3 | 0.1 | 87.0 |
| Cpz | Carboxypeptidase Z | 16.8 | 1.8 | 8.9 |
| Growth factors and TFs | ||||
| Ndrg1 | N-myc downstream regulated 1 | 645.4 | 132.4 | 4.9 |
| Igfbp6 | Insulin-like growth factor binding protein 6 | 563.7 | 29.5 | 19.0 |
| Igfbp7 | Insulin-like growth factor binding protein 7 | 500.7 | 90.9 | 5.5 |
| Sema3b | Semaphorin 3B | 381.9 | 104.2 | 3.7 |
| Lect1 | Leukocyte cell derived chemotaxin 1 | 344.2 | 79.4 | 4.3 |
| Sema5a | Semaphorin 5A | 94.9 | 17.4 | 5.4 |
| Fgf7 | Fibroblast growth factor 7 | 70.4 | 8.9 | 7.8 |
| Slit2 | Slit homolog 2 | 30.6 | 9.0 | 3.4 |
| Bmp1 | Bone morphogenetic protein 1 | 29.4 | 9.2 | 3.2 |
| Egr2 | Early growth response 2 | 27.4 | 8.8 | 3.1 |
| Sema4g | Semaphorin 4G | 21.2 | 5.1 | 4.1 |
| Foxo4 | Forkhead box O4 | 20.9 | 5.1 | 4.0 |
| Fzd2 | Frizzled homolog 2 | 16.4 | 2.8 | 5.7 |
| Bmp4 | Bone morphogenetic protein 4 | 10.5 | 1.0 | 9.6 |
| Fgf4 | Fibroblast growth factor 4 | 9.1 | 1.2 | 7.1 |
| Proteostasis | ||||
| Cryab | Crystallin, alpha B | 664.6 | 108.3 | 6.1 |
| Ctsh | Cathepsin H | 203.0 | 51.4 | 3.9 |
| Hspa2 | Heat shock 70kDa protein 2 | 111.6 | 20.4 | 5.4 |
| Hspb2 | Heat shock 27kDa protein 2 | 43.2 | 10.1 | 4.2 |
| Psmb8 | Proteasome subunit beta type-8 | 7.0 | 2.2 | 3.2 |
| Metal handling | ||||
| Fth1 | Ferritin heavy chain | 8316.5 | 1696.3 | 4.9 |
| S100a6 | S100a6 | 1498.6 | 471.6 | 3.2 |
| S100a4 | S100a6 | 526.9 | 81.8 | 6.4 |
| Sepp1 | Selenoprotein P | 469.2 | 103.2 | 4.5 |
| Tf | Transferrin | 151.7 | 21.9 | 6.9 |
| S100a3 | S100a3 | 39.4 | 6.8 | 5.7 |
| Complement | ||||
| C1r | Complement C1r subcomponent | 90.0 | 12.1 | 7.4 |
| C1s | Complement C1s subcomponent | 88.0 | 9.3 | 9.3 |
| C4b | Complement C4-B | 42.6 | 0.6 | 61.6 |
| C2 | Complement C2 | 33.1 | 3.3 | 9.7 |
| C1qc | Complement C1q subcomponent subunit C | 29.4 | 6.5 | 4.5 |
| C1ql3 | Complement C1q-like protein 3 | 27.7 | 5.6 | 4.9 |
| C1qa | Complement C1q subcomponent subunit A | 27.4 | 5.5 | 4.9 |
| C6 | Complement component C6 | 10.9 | 0.4 | 23.9 |
| C1qtnf6 | Complement C1q tumor necrosis factor-related protein | 10.5 | 1.9 | 5.4 |
| C1qtnf9 | Complement C1q tumor necrosis factor-related protein | 4.0 | 0.4 | 8.2 |
*
Fold enrichment is smaller in the sciatic nerve relative to the DRG because sciatic nerve Schwann cells are represented in the DRG.