Table 4.

Transcriptional profiline of pain channelopathy genes

Gene name	Protein name	Pain phenotype(s)	Trpv1 Enriched	Trpv1 depleted	DRG	Sciatic	DRG	Tibial
			Mouse		Rat		Human
SCN10A	Nav1.8	Gain of function: painful neuropathy	214.8	59.7	79.2	0.0	26.8	0.0
SCN11A	Nav1.9	Gain of function: HSAN7, insensitivity to pain	169.2	16.4	59.5	0.0	91.9	0.3
TRPV1	TRPV1	SNPs correlate with neuropathic pain, migraine. Loss of function causes insensitivity to capsaicin. Gain of function painful.	151.2	1.3	31.5	2.5	39.1	0.6
SCN9A	Nav1.7	Loss of function: insensitivity to pain Gain of function: paroxysmal extreme pain disorder, small fiber neuropathy, erythermalgia, HSAN2D	53.9	31.1	44.2	1.7	40.6	3.1
TRPA1	TRPA1	Gain of function: familial episodic pain syndrome	23.6	0.9	14.4	0.2	9.7	0.0

Abbreviations: HSAN - hereditary sensory and autonomic neuropathy; SNP - single nucleotide polymorphism.