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. 2016 Apr 19;25(12):2498–2513. doi: 10.1093/hmg/ddw114

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Figure 7. — The effect of DAPK1 KO on APP processing in the Tg2576 APP transgenic mice. (A) APP processing in the brains of 8-month-old Tg2576/WT or Tg2576/DAPK1 KO mice was examined (3M, 3F). Total APP (G12A), sAPPα (6E10), sAPPβ-swedish (IBL), APP-CTFα (G12A), APP-CTFβ (G12A) and pThr668-APP were detected. (B) Densitometric analysis of APP-CTFα, APP-CTFβ, sAPPα, and sAPPβ and ratios of CTFβ:CTFα and sAPPβ:sAPPα (*P < 0.05; ANOVA/Dunnett’s test). (C) Densitometric analysis of pThr668-APP. (*P < 0.05; ANOVA/Dunnett’s test).