Table II.

Dysregulated miRNAs in patients 2203 and 1674.

miRNA ID	Patient 2203 vs. normal pool			Patient 1674 vs. normal pool
	Fold-change	P-value	adj-P-value	Fold-change	P-value	adj-P-value
Common miRNAs
Upregulated
hsa-miR-210	13.694	4.119×10−09	1.110×10−06	18.204	1.344×10−09	9.051×10−07
hsa-miR-155-5p	6.695	7.973×10−06	4.130×10−04	7.965	2.615×10−04	2.887×10−03
hsa-miR-342-3p	3.389	1.927×10−06	1.527×10−04	3.132	1.483×10−07	1.537×10−05
hsa-miR-34a-5p	3.373	2.187×10−04	3.983×10−03	2.519	7.045×10−04	5.858×10−03
hsa-miR-1274a	2.853	1.377×10−04	2.995×10−03	2.441	3.774×10−05	7.159×10−04
hsa-miR-720	2.773	9.353×10−05	2.348×10−03	2.265	9.233×10−05	1.353×10−03
hsa-miR-122-5p	2.696	9.032×10−06	4.345×10−04	3.808	4.595×10−05	8.253×10−04
hsa-miR-150-5p	2.645	1.554×10−04	3.271×10−03	3.333	7.686×10−05	1.204×10−03
hsa-miR-1274b	2.531	6.167×10−04	7.416×10−03	2.235	1.829×10−05	4.663×10−04
hsa-miR-34b-5p	2.472	1.131×10−03	1.199×10−02	2.239	7.917×10−05	1.226×10−03
hsa-miR-106b-5p	2.463	8.830×10−03	4.815×10−02	2.191	1.354×10−06	7.601×10−05
hsa-miR-25-3p	2.361	5.440×10−05	1.629×10−03	2.343	3.438×10−07	2.724×10−05
hsa-miR-93-5p	2.342	3.627×10−05	1.164×10−03	2.209	1.910×10−07	1.838×10−05
hsa-miR-885-5p	2.059	7.217×10−05	1.984×10−03	2.749	4.733×10−04	4.438×10−03
Downregulated
hsa-miR-762	−2.148	6.373×10−04	7.597×10−03	−2.456	3.143×10−06	1.520×10−04
hsa-miR-4270	−2.167	1.655×10−03	1.538×10−02	−2.318	7.754×10−06	2.611×10−04
hsa-miR-218-5p	−2.259	1.106×10−04	2.701×10−03	−2.030	3.164×10−03	1.661×10−02
hsa-miR-30a-3p	−2.371	3.591×10−05	1.164×10−03	−2.185	6.318×10−05	1.051×10−03
hsa-miR-1207-5p	−2.380	2.682×10−03	2.101×10−02	−2.425	7.777×10−04	6.349×10−03
hsa-miR-199a-3p	−2.382	5.068×10−03	3.354×10−02	−3.405	6.913×10−03	3.053×10−02
hsa-miR-188-5p	−2.474	3.029×10−05	1.046×10−03	−2.172	3.194×10−06	1.520×10−04
hsa-miR-30c-5p	−2.477	2.188×10−04	3.983×10−03	−2.108	3.468×10−05	6.970×10−04
hsa-miR-1225-5p	−2.485	3.166×10−03	2.331×10−02	−2.403	7.302×10−04	6.034×10−03
hsa-miR-4286	−2.487	1.325×10−09	7.936×10−07	−2.279	6.848×10−08	1.004×10−05
hsa-miR-30a-5p	−2.490	8.286×10−06	4.134×10−04	−2.253	5.463×10−06	2.230×10−04
hsa-miR-4284	−2.718	3.360×10−03	2.446×10−02	−4.295	7.493×10−06	2.611×10−04
hsa-miR-660-5p	−2.813	4.062×10−05	1.244×10−03	−2.239	4.978×10−04	4.530×10−03
hsa-miR-642b-3p	−2.863	3.629×10−05	1.164×10−03	−2.775	4.850×10−08	1.004×10−05
hsa-miR-135a-5p	−2.965	1.202×10−06	1.233×10−04	−2.413	3.352×10−06	1.520×10−04
hsa-miR-630	−3.208	2.354×10−03	1.880×10−02	−3.347	3.092×10−08	8.330×10−06
hsa-miR-363-3p	−3.319	2.369×10−04	4.200×10−03	−2.378	1.989×10−05	4.871×10−04
hsa-miR-200b-3p	−3.577	5.841×10−05	1.684×10−03	−2.609	2.844×10−05	5.918×10−04
hsa-miR-429	−3.657	1.300×10−04	2.917×10−03	−2.893	2.199×10−05	5.197×10−04
hsa-miR-1202	−3.772	6.780×10−04	7.613×10−03	−2.993	1.971×10−03	1.149×10−02
hsa-miR-141-3p	−9.901	1.767×10−09	7.936×10−07	−9.272	9.951×10−07	5.828×10−05
hsa-miR-200c-3p	−12.485	3.817×10−09	1.110×10−06	−11.832	9.017×10−07	5.784×10−05
Specific miRNAs of patient 2203
Upregulated
hsa-miR-21-3p	2.705	1.544×10−05	6.710×10−04	1.845	1.092×10−03	7.619×10−03
hsa-miR-1260b	2.461	2.786×10−04	4.750×10−03	1.968	1.898×10−04	2.265×10−03
hsa-miR-320d	2.359	1.634×10−04	1.538×10−02	1.756	3.132×10−03	1.654×10−02
hsa-miR-181b-5p	2.339	4.412×10−08	9.083×10−06	1.983	3.519×10−05	6.970×10−04
hsa-miR-1260a	2.261	6.489×10−04	7.613×10−03	1.922	8.246×10−04	6.573×10−03
hsa-miR-452-5p	2.245	4.431×10−03	3.045×10−02	1.382	1.265×10−02	4.801×10−02
hsa-miR-130b-3p	2.243	1.656×10−06	1.394×10−04	1.742	2.452×10−06	1.270×10−04
hsa-miR-320e	2.178	5.735×10−04	7.087×10−03	1.837	2.525×10−05	5.755×10−04
hsa-miR-320b	2.168	7.956×10−04	8.856×10−03	1.714	2.918×10−04	3.144×10−03
hsa-miR-342-5p	2.129	1.601×10−05	6.741×10−04	1.971	1.339×10−07	1.503×10−05
hsa-miR-223-3p	2.056	2.665×10−04	4.602×10−03	1.867	9.326×10−03	3.830×10−02
hsa-miR-181a-5p	2.019	9.307×10−04	1.011×10−02	1.932	1.444×10−05	4.052×10−04
Downregulated
hsa-miR-362-3p	−2.317	5.680×10−04	7.087×10−03	−1.826	2.457×10−03	1.385×10−02
hsa-miR-200a-3p	−2.552	1.657×10−04	3.433×10−03	−1.575	3.224×10−02	ns
hsa-miR-10a-5p	−3.326	4.392×10−04	5.915×10−03	−1.965	4.617×10−02	ns
Specific miRNAs of patient 1674
Upregulated
hsa-miR-142-3p	2.941	2.613×10−02	ns	4.372	1.588×10−03	9.811×10−03
hsa-miR-489	1.231	ns	ns	3.434	1.139×10−02	4.447×10−02
hsa-miR-142-5p	2.116	ns	ns	3.205	1.006×10−03	7.348×10−03
hsa-miR-494	1.975	1.863×10−03	1.647×10−02	2.621	1.116×10−03	7.709×10−03
hsa-miR-126-3p	1.940	1.606×10−03	1.538×10−02	2.191	1.047×10−04	1.454×10−03
hsa-miR-15a-5p	1.569	ns	ns	2.187	1.493×10−05	4.103×10−04
hsa-miR-15b-5p	1.045	1.237×10−02	ns	2.181	1.112×10−03	1.488×10−03
hsa-miR-455-5p	1.230	ns	ns	2.096	4.226×10−05	7.798×10−04
hsa-miR-140-3p	1.840	5.298×10−04	6.796×10−03	2.032	1.710×10−04	2.105×10−03
hsa-miR-4306	1.368	3.099×10−03	2.306×10−02	2.005	3.613×10−04	3.632×10−03
hsa-miR-185-5p	1.387	2.402×10−02	ns	2.005	9.862×10−04	7.339×10−03
Downregulated
hsa-miR-4299	−1.489	ns	ns	−2.035	1.415×10−05	4.052×10−04
hsa-miR-4254	−1.879	3.745×10−03	2.660×10−02	−2.081	3.636×10−06	1.531×10−04
hsa-miR-204-5p	−5.917	2.029×10−02	ns	−2.12	8.344×10−03	3.491×10−02
hsa-miR-1268a	−1.486	ns	ns	−2.264	1.260×10−05	3.689×10−04
hsa-miR-574-3p	−1.526	3.078×10−02	ns	−2.314	9.952×10−07	5.828×10−05
hsa-miR-10b-5p	−1.881	1.377×10−02	ns	−2.338	8.231×10−03	3.463×10−02
hsa-let-7a-5p	−1.933	1.263×10−03	1.288×10−02	−2.377	1.679×10−03	1.014×10−02
hsa-miR-4281	−1.917	7.692×10−03	4.525×10−02	−2.529	8.819×10−05	1.320×10−03

miR, microRNA; ns, not significant.