Table III.
Summary of major implicated pathways in VHL-associated and sporadic renal tumors.
| KEGG ID | KEGG description | KEGG subclass | KEGG class |
|---|---|---|---|
| Common pathways in both tumor groups | |||
| hsa04115 | p53 signaling pathway | Cell growth and death | Cellular processes |
| hsa04510 | Focal adhesion | Cellular community | |
| hsa04540 | Gap junction | ||
| hsa04060 | Cytokine-cytokine receptor interaction | Signaling molecules and interaction | Environmental information processing |
| hsa04514 | Cell adhesion molecules (CAMs) | ||
| hsa04512 | ECM-receptor interaction | ||
| hsa05200 | Pathways in cancer | Cancers: Overview | Human diseases |
| hsa03320 | PPAR signaling pathway | Endocrine system | Organismal systems |
| hsa04960 | Aldosterone-regulated sodium reabsorption | Excretory system | |
| hsa04610 | Complement and coagulation cascades | Immune system | |
| hsa04650 | Natural killer cell mediated cytotoxicity | ||
| hsa04640 | Hematopoietic cell lineage | ||
| hsa04672 | Intestinal immune network for IgA production | ||
| hsa04610 | Complement and coagulation cascades | ||
| hsa04062 | Chemokine signaling pathway | ||
| hsa04612 | Antigen processing and presentation | ||
| hsa04621 | NOD-like receptor signaling pathway | ||
| hsa04660 | T cell receptor signaling pathway | ||
| hsa04670 | Leukocyte transendothelial migration | ||
| hsa00532 | Chondroitin sulfate biosynthesis | Glycan biosynthesis and metabolism | Metabolism |
| hsa00280 | Valine, leucine and isoleucine degradation | Amino acid metabolism | |
| hsa00380 | Tryptophan metabolism | ||
| hsa00330 | Arginine and proline metabolism | ||
| hsa00260 | Glycine, serine and threonine metabolism | ||
| hsa00250 | Alanine, aspartate and glutamate metabolism | ||
| hsa00340 | Histidine metabolism | ||
| hsa00310 | Lysine degradation | ||
| hsa00270 | Cysteine and methionine metabolism | ||
| hsa00350 | Tyrosine metabolism | ||
| hsa00640 | Propanoate metabolism | Carbohydrate metabolism | |
| hsa00650 | Butanoate metabolism | ||
| hsa00620 | Pyruvate metabolism | ||
| hsa00020 | Citrate cycle (TCA cycle) | ||
| hsa00053 | Ascorbate and aldarate metabolism | ||
| hsa00010 | Glycolysis/gluconeogenesis | ||
| hsa00040 | Pentose and glucuronate interconversions | ||
| hsa00500 | Starch and sucrose metabolism | ||
| hsa00630 | Glyoxylate and dicarboxylate metabolism | ||
| hsa00190 | Oxidative phosphorylation | Energy metabolism | |
| hsa00910 | Nitrogen metabolism | ||
| hsa00071 | Fatty acid metabolism | Global and overview maps | |
| hsa00072 | Synthesis and degradation of ketone bodies | Lipid metabolism | |
| hsa00140 | Steroid hormone biosynthesis | ||
| hsa00120 | Primary bile acid biosynthesis | ||
| hsa00590 | Arachidonic acid metabolism | ||
| hsa00062 | Fatty acid elongation in mitochondria | ||
| hsa00830 | Retinol metabolism | Metabolism of cofactors and vitamins | |
| hsa00410 | β-Alanine metabolism | Metabolism of other amino acids | |
| hsa00480 | Glutathione metabolism | ||
| hsa00903 | Limonene and pinene degradation | Metabolism of terpenoids and polyketides | |
| hsa00982 | Drug metabolism-cytochrome P450 | Xenobiotics biodegradation and metabolism | |
| hsa00980 | Metabolism of xenobiotics | ||
| by cytochrome P450 | |||
| hsa00983 | Drug metabolism-other enzymes | ||
| Specific to VHL-associated tumors | |||
| hsa04330 | Notch signaling pathway | Signal transduction | Environmental information processing |
| hsa00900 | Terpenoid backbone biosynthesis | Metabolism of terpenoids and polyketides | Metabolism |
| Specific to sporadic tumors | |||
| hsa04110 | Cell cycle | Cell growth and death | Cellular processes |
| hsa04630 | Jak-STAT signaling pathway | Signal transduction | Environmental information processing |
| hsa04666 | FcγR-mediated phagocytosis | Immune system | Organismal systems |
| hsa04662 | B cell receptor signaling pathway | ||
| hsa04620 | Toll-like receptor signaling pathway | ||
| hsa01040 | Biosynthesis of unsaturated fatty acids | Lipid metabolism | Metabolism |
| hsa00100 | Steroid biosynthesis | ||
| hsa00360 | Phenylalanine metabolism | Amino acid metabolism |
VHL, von Hippel-Lindau.