Table I.
The association of between HOXA3 mRNA expression in NSCLC tissues and patient clinicopathological characteristics based on RT-qPCR detection.
| Clinicopathological characteristics | Case no. | HOXA3 expression
|
t-test of data
|
|||
|---|---|---|---|---|---|---|
| Mean | SD | FC | t-test | P-value | ||
| Group | ||||||
| Control | 55 | 0.19 | 0.20 | 1.00 | 2.86 | 0.006 |
| Cancer | 55 | 0.11 | 0.14 | 0.60 | ||
| Pathological type | ||||||
| Adenocarcinoma | 32 | 0.13 | 0.17 | 1.00 | 0.99 | 0.326 |
| Squamous cell carcinoma | 23 | 0.09 | 0.08 | 0.70 | ||
| LUAD | ||||||
| Control | 32 | 0.23 | 0.24 | 1.00 | −1.94 | 0.023 |
| Cancer | 32 | 0.13 | 0.17 | 0.55 | ||
| LUAD | ||||||
| Non-smoker | 18 | 0.18 | 0.20 | 1.00 | 2.42 | 0.025 |
| Smoker | 14 | 0.06 | 0.04 | 0.32 | ||
| LUSC | ||||||
| Control | 23 | 0.12 | 0.09 | 1.00 | −1.32 | 0.034 |
| Cancer | 23 | 0.09 | 0.08 | 0.73 | ||
| Sex | ||||||
| Male | 41 | 0.12 | 0.15 | 1.00 | 0.35 | 0.732 |
| Female | 14 | 0.10 | 0.12 | 0.87 | ||
| Age (years) | ||||||
| <60 | 35 | 0.12 | 0.15 | 1.00 | 0.25 | 0.801 |
| ≥60 | 20 | 0.11 | 0.12 | 0.91 | ||
| Smoking | ||||||
| No | 30 | 0.14 | 0.17 | 1.00 | 1.91 | 0.064 |
| Yes | 25 | 0.08 | 0.06 | 0.54 | ||
| Size | ||||||
| ≤3 cm | 16 | 0.12 | 0.12 | 1.00 | 0.09 | 0.931 |
| >3 cm | 39 | 0.11 | 0.15 | 0.97 | ||
| LNM | ||||||
| No | 29 | 0.08 | 0.10 | 1.00 | −1.66 | 0.103 |
| Yes | 26 | 0.14 | 0.17 | 1.78 | ||
| TNM | ||||||
| I–II | 29 | 0.09 | 0.11 | 1.00 | −1.26 | 0.212 |
| III–IV | 26 | 0.14 | 0.17 | 1.54 | ||
| Vascular invasion | ||||||
| No | 50 | 0.11 | 0.15 | 1.00 | 0.23 | 0.817 |
| Yes | 5 | 0.10 | 0.03 | 0.85 | ||
| Clinical grading | ||||||
| I | 5 | 0.09 | 0.08 | 0.664 | ||
| II | 40 | 0.12 | 0.16 | |||
| III | 10 | 0.08 | 0.07 | |||
HOXA3, homeobox A3, an mRNA of homeobox genes of clusters A; NSCLC, non-small cell lung cancer; LUAD, lung adenocarcinoma; LUSC, lung squamous cell carcinoma; RT-qPCR, reverse transcription-quantitative polymerase chain reaction; SD, standard deviation; FC, fold change; LNM, lymph node metastasis. An independent sample t-test was adopted to test the data and single factor ANOVA was used to test the clinical grading data. The difference between the cancer and normal adjacent group was analyzed by a paired-samples t-test.