Table 1.
Clinical and laboratory data of hemophiliac children according to HCV-antibody and HCV-PCR status.
| HCV-antibody positive (n=40) | HCV-antibody negative (n=60) | P | HCV-PCR positive (n=19) | HCV-PCR negative (n=21) | P | |
|---|---|---|---|---|---|---|
|
| ||||||
| Mean age in years (SD) | 10.6 (3.5) | 7.30 (3.9) | .001 | 10.8 (4.0) | 8.1 (4.0) | .01 |
| Frequency of bleeds/year | 23.0 (12.7) | 9.8 (0.2) | .001 | 73.1 (33.8) | 47.9 (32.5) | .014 |
| Dose of replacement therapy/year | 70.4 (39.3) | 40.9 (24.0) | .001 | 29.6 (12.3) | 11.7 (8.0) | .001 |
| PTT (s) | 84.8 (10.6) | 83.4 (21.0) | .707 | 86.2 (10.6) | 83.5 (19.0) | .564 |
| PT (s) | 13.7 (1.4) | 13.7 (1.6) | .965 | 13.6 (0.6) | 13.7 (1.7) | .763 |
| AST (U/L) | 33.0 (27.3) | 25.6 (14.9) | .083 | 42.1 (36.1) | 25.4 (14.0) | .001 |
| ALT (U/L) | 42.4 (34.2) | 29.5 (2.4) | .025 | 53.9 (43.6) | 30.1 (21.3) | .031 |
PT: prothrombin time, PTT: partial thromboplastin time, ALT: alanine transaminase, AST: aspartate transaminase.