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Cumulative incidence of treatment change during follow-up among matched direct oral anticoagulant users and warfarin users with atrial fibrillation. *Baseline time for warfarin users (A) is the warfarin prescribed date matched with duration of previous warfarin use, in comparison with direct oral anticoagulant users (B). Thirty-nine percent of discontinuation of anticoagulant occurred after bleeding events.
