Table 2.

Diseases of the proximal tubule that may impair secretory clearance

Medication-induced injury

Nucleotide reverse transcription inhibitors (tenofovir)

Anticancer drugs (cisplatin, ifosfamide)

Antibiotics (aminoglycosides)

Ig disorders

Multiple myeloma

Light-chain tubulopathy

Amyloidosis

IGG4 disease

Other

Aristolochic acid nephropathy

Sjogren syndrome

Inherited genetic disorders (polycystic kidney disease, cystinosis, glycogen storage disease)

Heavy metal exposure (lead, cadmium, mercury)

IGG4, immunoglobulin G4-related disease.