Table 2.
Association of hemodialysis initiation with HDL-associated proteins
| Protein and Model | Ratio of Protein Concentrations Comparing Hemodialysis with Late-Stage CKDa | 95% Confidence Interval | q Value |
|---|---|---|---|
| Serum Amyloid A2 | |||
| Unadjusted | 2.21 | 1.19 to 4.09 | |
| Model 1b | 2.28 | 1.19 to 4.35 | 0.08 |
| Model 2c | 3.21 | 1.60 to 6.43 | 0.04 |
| Serum Amyloid A1 | |||
| Unadjusted | 1.62 | 1.07 to 2.45 | |
| Model 1 | 1.69 | 1.10 to 2.60 | 0.09 |
| Model 2 | 1.99 | 1.26 to 3.16 | 0.04 |
| Hemoglobin-β | |||
| Unadjusted | 1.89 | 1.25 to 2.87 | |
| Model 1 | 1.74 | 1.13 to 2.68 | 0.08 |
| Model 2 | 1.92 | 1.20 to 3.07 | 0.05 |
| Haptoglobin-Related Protein | |||
| Unadjusted | 1.89 | 1.42 to 2.52 | |
| Model 1 | 1.45 | 1.11 to 1.89 | 0.07 |
| Model 2 | 1.44 | 1.09 to 1.89 | 0.06 |
| Cholesterol Ester Transfer Protein | |||
| Unadjusted | 1.36 | 1.11 to 1.65 | |
| Model 1 | 1.34 | 1.09 to 1.65 | 0.07 |
| Model 2 | 1.30 | 1.05 to 1.62 | 0.08 |
| Phospholipid Transfer Proteind | |||
| Unadjusted | 1.34 | 1.10 to 1.63 | |
| Model 1 | 1.32 | 1.08 to 1.61 | 0.07 |
| Model 2 | 1.20 | 0.98 to 1.47 | 0.28 |
| Apolipoprotein E | |||
| Unadjusted | 1.34 | 1.14 to 1.57 | |
| Model 1 | 1.29 | 1.09 to 1.53 | 0.07 |
| Model 2 | 1.31 | 1.09 to 1.56 | 0.04 |
| Serum Amyloid A4e | |||
| Unadjusted | 1.17 | 1.02 to 1.35 | |
| Model 1 | 1.17 | 1.01 to 1.35 | 0.14 |
| Model 2 | 1.25 | 1.07 to 1.46 | 0.04 |
a
Ratio of geometric means.
b
Model 1 was adjusted for age, race (black versus nonblack), and sex.
c
Model 2 adds adjustment for diabetes, body mass index, prevalent cardiovascular disease, smoking, statin use, and serum levels of total cholesterol, HDL-C, and triglycerides.
d
PLTP was no longer statistically significant after model 2 adjustment.
e
SAA4 was significant after model 2 adjustment only.