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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: J Immunother. 2018 Sep;41(7):350–358. doi: 10.1097/CJI.0000000000000241

Table 3. Individual change in cognitive test scores from baseline to follow-up (day 21-28).

Fifteen subjects were able to complete cognitive tests at baseline and follow-up, with 12/15 demonstrating stable or improved scores on all four tests and two additional subjects showing stable/improved scores on three of four tests. Subject 18 demonstrated decreased test scores in three of four areas; this subject had significant disease burden post-infusion.

Patient DCCS Cognitive Flexibility Flanker Attention/Inhibiton List Sort Working Memory Wechsler PSI Processing Speed
1# N/A N/A N/A N/A
2 stable stable stable stable
3@ N/A N/A N/A N/A
4 stable stable stable stable
5 stable stable stable stable
6 stable stable stable increase
7 increase stable stable stable
8 stable increase stable increase
9 stable stable stable stable
10 stable stable stable decrease
11* N/A increase increase increase
12^ N/A N/A N/A N/A
13@ N/A N/A N/A N/A
14 stable stable stable increase
15$ N/A N/A N/A N/A
16 stable stable stable increase
17 stable stable stable stable
18 decrease decrease decrease stable
19^ N/A N/A N/A N/A
20 decrease stable increase increase
21 stable stable stable increase
22^ N/A N/A N/A N/A

DCCS = Dimensional Change Card Sort; PSI=Processing Speed Index

Significant increase or decrease in scores was defined as a difference of ≥ .75 SD (11 points) from testing at baseline to Day 28; tests have a normative mean of 100 and SD of 15; higher scores are better

#

Patient 1 could not complete follow-up cognitive testing due to significant disease progression

@

Patients 3 and 13 declined to complete follow-up assessments

*

Patient 11 could not complete one follow-up cognitive flexibility test due to computer problems

^

Patients 12, 19, and 22 could not complete the cognitive testing due to trisomy 21 due to concerns about comprehending the instructions and ongoing validation of the NIH Toolbox tests in individuals with intellectual disability.18

$

Patient 15 could not complete the baseline cognitive testing due to significant nausea/illness