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. Author manuscript; available in PMC: 2019 Aug 9.
Published in final edited form as: Cell. 2018 Jul 26;174(4):870–883.e17. doi: 10.1016/j.cell.2018.06.029

Figure 6. The induction of cell-non-autonomous UPRmt signaling upon neuronal Wnt/EGL-20 expression is dependent on the retromer complex and canonical Wnt signaling.

Figure 6

(A) Representative photomicrographs of rgef-1p∷egl-20; hsp-6p∷gfp reporter animals in WT, vps-35, bar-1 RNAi, or pop-1 RNAi background.

(B) Quantification of hsp-6p∷gfp expression. The genotypes are as in (A).

(C) Immunoblot of GFP expression. The genotypes are as in (A).

(D) Representative photomicrographs of gly-19p∷egl-20; hsp-6p∷gfp reporter animals in WT, vps-35, bar-1 RNAi, or pop-1 RNAi background.

(E) Quantification of hsp-6p∷gfp expression. The genotypes are as in (D).

(F) Immunoblot of GFP expression. The genotypes are as in (D).

*** p< 0.0001 via t-test. Error bars, SEM. n ≥ 15 worms.

See also Figure S6.