Table 1.
Description of the patients in the program, mean age: 33.6 years (4.9). SPr spontaneous pregnancy, misc. miscarriage, Hcy homocysteine
| Case (women age) | Genetic background | Infertility/failures | TT duration (months) | Result | |
|---|---|---|---|---|---|
| Women | Man | ||||
| AS/EJS (31) | HMZ 1298CC | WT | 4 misc | 4 | SPr: normal delivery (male) |
| BE/EJS (29) | HMZ 677TT | HMZ 1298CC | Unexplained | 4 | SPr: pregnant 28 weeks |
| RK/EJS (31) | HMZ 677TT | WT | 4 years, 4 failed IUI | 4 | SPr: pregnant 21 weeks |
| BL/EJS (34)* | HMZ 677TT | WT | 2 misc./POF | 4 | SPr: pregnant 18 weeks |
| KD/EJS (28) | HMZ 1298CC | WT | Failed ovarian Stim | 4 | Ovarian stimulation: Pregnant 30 weeks |
| JP/LF (38) | HTZ677CT | HTZ677CT | 8 misc. (4IUI), 1 IVF | 4 | SPr: delivery (female) |
| ND/LF (37) | HTZ677CT | HTZ677CT | 6 misc | 4 | Pr post ovarian stimulation: delivery (female) |
| Ma/ LF (32) | HTZ677CT | HTZ677CT | 3 misc | 4 | SPr: delivery (female) |
| Va/LF* (37) | HTZ677CT | HTZ677CT | 2 misc., 1 ectopic | 4 | SPr: 30 weeks |
| HS/EJS (26) | HTZ677CT | HTZ677CT | 3 misc | 3 | SPr: 32 weeks |
| Ca/LF (40) | HMZ677TT | HTZ677CT | 6 misc | 4 | Twin Pregnancy post ovarian Stimulation: 20 weeks |
| Bou/LF (33) | HTZ677CT | HMZ677TT | 3 misc | 6 | One failed ovarian stimulation, then SPr: 14 weeks |
| BBM/DC (36) | HMZ677TT | HTZ677CT | 4 misc | 4 | Two failed IUI |
| DC/DC (38) | HMZ677TT | HTZ677CT | 2 failed IVF | 7 | Pregnant post IVF, 6 mths |
| Ib/MC (38) | HTZ677CT | HTZ677CT | 2 failed IVFs | 4 | Failed 3rd IVF |
| La/MC (33) | HTZ677CT | HTZ677CT | 2 failed IVFs | 4 | Failed 3rd IVF |
| Du/MC (42) | HMZ677TT | HTZ677CT | 2 failed IVFs | 4 | IUI: Twin pregnancy 6 months |
| Go/MC (28) | HTZ677CT | HTZ677CT | 5 failed IUI | 4 | Pr post IVF, 6.5 months |
| Ha/MC (38) | HTZ677CT | HTZ677CT | 2 misc | 4 | SPr: miscarriage |
| Be/MC (39) | HMZ677TT | HTZ677CT | Unexplained Primary | 4 | Spr: delivery (male) |
| Be/MC (39) | HMZ677TT | HMZ677TT | Unexplained | 4 | Pr post IVF: delivery female baby |
| Ba/MC (31) | HMZ677TT | HTZ677CT | PCOS, high Hcy | 5 | Pregnancy post IVF: delivery (female) |
| Bi/MC (26) | HMZ677TT | HMZ677TT | PCOS, endometriosis | 6 | Pr post IVF: delivery female baby |
| Sa/MC (37) | HMZ677TT | HTZ677CT | Unexplained primary | 4 | Pr post IVF: delivery female baby |
| Vi/MC (34) | HMZ677TT | HMZ677TT | Unexplained primary | 4 | Pr post IVF: delivery female baby |
| Yi/MC (26) | HMZ677TT | HTZ677CT | Unexplained primary | 6 | 3 failed IUI, Pr post IVF, delivery female baby |
| GSt/MC (35) | HMZ677TT | HMZ677TT | 8 misc | 4 | Spr 6.5 months |
| VM/EJS (35) | 677CT/1298AC | HTZ1298AC | Biochemical Pr | 4 | Spr: 10 weeks |
| AyM/MC (23) | HTZ677CT | HTZ677CT | 3 misc | 4 | Pr 6 months post IVF |
| MS/MC (32) | HMZ677TT | HTZ677CT | 7 misc | 5 | SPr 10 weeks |
HMZ homozygote, HTZ heterozygote, WT wild type (no mutation), POF premature ovarian failure
*Patients counseled for oocyte donation before entering the program