Table 1.
Prediction of activated/inhibited signalling in HUVECs treated with exosomes released from PK-45H cells.
| Upstream regulator | Molecule type | Predicted activation state | Activation z-score |
|---|---|---|---|
| PDGF BB | Complex | Activated | 2.881 |
| HRAS | Enzyme | Activated | 2.739 |
| VAGFA | Growth factor | Activated | 2.529 |
| HSP90 | Group | Activated | 2.488 |
| EDN1 | Cytokine | Activated | 2.462 |
| TRAF6 | Enzyme | Activated | 2.407 |
| AKT | Group | Activated | 2.273 |
| ERK1/2 | Group | Activated | 2.118 |
| U0126 | Chemical–kinase inhibitor | Inhibited | −2.485 |
| Sulforaphane | Chemical drug | Inhibited | −2.747 |