Autophagic Vacuole Formation: |
Atg4b, Atg4c, Atg9a, Gabarap, Gabarapl1, Gabarapl2, Wipi1, Becn1, Ulk1, Map1lc3 |
Ubiquitination and phagophore expansion: |
Atg12, Atg16l1, Atg16l2, Atg3, Atg5, Atg7, Hdac6, Map1lc3a |
Vacuole targeting and autophagosome-lysosome Linkage |
Lamp1, Npc1, Gabarap, Atg4b, Atg4c |
Chaperone-mediated autophagy |
Hsp90aa1, Hspa8 |
Regulation of Autophagy
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Co-Regulators of autophagy and apoptosis |
Dram1, Akt1, App, Atg12, Atg5, Bad, Bak1, Bax, Bcl2, Bcl2l1 (BclXL), Becn1,Bid, Bnip3, Casp3, Casp8 (FLICE), Cdkn1b (p27Kip1), Cdkn2a (p16INK4a), Cln3, Ctsb, Cxcr4, Dapk1, Eif2ak3, Fadd, Fas(Tnfrsf6), Hdac1, Htt, Ifng, Igf1, Ins2, Mapk8 (JNK1), Mtor, Nfkb1, Pik3cg, Prkaa1 (Ampk), Pten, Snca, Sqstm1, Tgfb1, Tgm2,Tnf, Tnfsf10 (Trail), Trp53 (p53). |
Co-Regulators of autophagy and the cell cycle |
Bax, Cdkn1b (p27Kip1), Cdkn2a (p16INK4a), Ifng, Pten, Rb1, Tgfb1, Trp53 (p53). |
Autophagy induction by intracellular pathogens |
Eif2ak3, Ifng, Lamp1. |
Autophagy in response to other intracellular signals |
Ctsd, Ctss, Dram2 (Tmem77), Eif4g1, Esr1 (Erα), Gaa, Hgs, Mapk14(p38alpha), Pik3c3 (Vps34), Pik3r4, Rps6kb1, Tmem74, Ulk2, Uvrag. |