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. 2018 Aug 10;8:11991. doi: 10.1038/s41598-018-30360-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cell morphometric analysis. Sketch of cell morphology and orientation along the collagen stripe (a). D_max and D_min are the long and short axis, θ the angle of orientation of the cells. Cell elongation is quantitatively evaluated through the elongation factor (b). A significant elongation between the two types of samples is evident in (b). Box plots of cell areas (c) and scatter box plots of circularity distributions (d) are shown in the bottom panel. A significant difference was found in cell circularity between cells seeded on FPC and GPC. Notes: *p < 0.005, each box has its ends at the quartiles, and the band within the boxes is the median of the distribution ((c), (d)).