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. 2018 Aug 10;8:11955. doi: 10.1038/s41598-018-29878-6

Figure 7.

Figure 7

AEBP1 modulates epithelial-mesenchymal transition of gastric cancer cells by functioning as an important upstream regulator of the NF-κB pathway. (A) Representative images of transwell invasion assays showing TNF-α (10 ng/mL) treatment significantly reversed the impaired invasive capabilities due to knockdown of AEBP1; magnification: 200×. (B) Quantification of the transwell invasion assay results; **P < 0.01. (C) Western blotting analyses of p-p65, MMP2, vimentin and E-cadherin expression after TNF-α (10 ng/mL) treatment in mock and sh-AEBP1-1 XN0422 and MGC803 cells. (D) Western blotting analyses of AEBP1, p-p65, MMP2, vimentin and E-cadherin expression after BAY 11–708 treatment in mock and sh-AEBP1-1 XN0422 and MGC803 cells. The western blots were derived under the same experimental conditions from the same cell lysates; the original full-length Western blot images are shown in Supplementary Fig. S6.