Table 3.
Multivariate analysis for evaluating the risk of sepsis in the derivation cohort based on the PCT/HLA-DRA ratio or Procalcitonin levels.
| Multivariate analysis for PCT/HLA-DRA ratio | Multivariate analysis for PCT | |||||||
|---|---|---|---|---|---|---|---|---|
| OR | [CI 95%] | p | OR | [CI 95%] | p | |||
| SOFA Score | 1.47 | 1.16 | 1.87 | 0.002 | 1.49 | 1.17 | 1.90 | 0.001 |
| Age | 1.00 | 0.94 | 1.06 | 0.873 | 1.01 | 0.96 | 1.07 | 0.714 |
| Urgent Surgery | 45.70 | 7.02 | 297.33 | <0.001 | 41.57 | 6.77 | 255.39 | <0.001 |
| Chronic Renal Failure | 8.09 | 0.40 | 165.00 | 0.174 | 4.74 | 0.26 | 86.12 | 0.293 |
| Cancer | 1.08 | 0.29 | 4.00 | 0.908 | 1.24 | 0.33 | 4.60 | 0.748 |
| Diabetes Mellitus | 2.89 | 0.69 | 12.22 | 0.149 | 2.41 | 0.61 | 9.57 | 0.210 |
| Neutrophil concentration in blood (cells/mm3) | 1.00 | 1.00 | 1.00 | 0.467 | 1.00 | 1.00 | 1.00 | 0.436 |
| C-Reactive Protein | 1.00 | 1.00 | 1.01 | 0.026 | 1.00 | 1.00 | 1.01 | 0.021 |
| PCT/HLA-DRA > OOP (0.0003) | 7.66 | 1.82 | 32.29 | 0.006 | — | — | — | — |
| PCT > OOP (1.115 ng/mL) | — | — | — | — | 4.21 | 1.15 | 15.43 | 0.030 |
OOP: Optimal operating point.