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. 2018 Aug 10;8:11993. doi: 10.1038/s41598-018-30506-6

Table 4.

Quality of life score according to the stage of cervical cancer and treatment modalities.

QLQ Items Stage P Clrel* Treatment P Clrel*
I II III IV Surgery S + C + R C/R
N = 103 N = 119 N = 20 N = 14 N = 60 N = 137 N = 59
C30 Functional scales
Global health status/ QOL 70.5 ± 21.8 66.1 ± 21.0 55.8 ± 24.2 33.3 ± 17.9 0.000 Yes 75.8 ± 18.6 66.8 ± 22.9 51.1 ± 20.6 0.000 Yes
Physical functioning 87.7 ± 21.8 83.5 ± 22.1 85.0 ± 20.9 66.7 ± 24.4 0.003 Yes 89.8 ± 16.9 83.0 ± 16.0 81.6 ± 17.4 0.000 No
Role functioning 87.7 ± 21.8 83.5 ± 22.1 85.0 ± 20.9 66.7 ± 24.4 0.003 Yes 91.7 ± 16.1 82.7 ± 24.0 80.8 ± 22.5 0.003 Yes
Emotional functioning 79.5 ± 18.9 81.4 ± 16.9 80.8 ± 20.2 75.0 ± 21.2 0.714 No 79.4 ± 19.9 80.6 ± 17.3 80.2 ± 18.6 0.991 No
Cognitive functioning 80.7 ± 17.2 79.4 ± 20.5 85.0 ± 19.4 73.8 ± 22.4 0.413 No 81.1 ± 19.9 78.1 ± 19.2 83.6 ± 18.4 0.124 No
Social functioning 76.4 ± 25.3 68.9 ± 25.8 61.7 ± 31.6 59.5 ± 34.4 0.034 Yes 81.7 ± 21.8 70.9 ± 25.6 59.6 ± 30.5 0.000 Yes
C30 Symptom scales
Fatigue 22.6 ± 21.7 24.6 ± 16.4 28.9 ± 21.1 36.5 ± 22.8 0.036 Yes 20.4 ± 22.2 25.7 ± 19.0 27.3 ± 17.3 0.014 No
Nausea & vomiting 9.2 ± 15.2 18.3 ± 24.3 20.0 ± 25.1 28.6 ± 35.5 0.009 Yes 6.7 ± 16.0 14.5 ± 17.8 26.3 ± 32.0 0.000 Yes
Pain 15.8 ± 22.4 17.9 ± 18.3 23.3 ± 20.5 21.4 ± 25.7 0.166 No 11.1 ± 20.9 18.4 ± 19.4 22.9 ± 21.6 0.000 Yes
Dyspnoea 11.6 ± 18.5 15.1 ± 19.8 6.7 ± 13.7 19.0 ± 25.1 0.174 No 6.7 ± 16.0 16.0 ± 20.2 13.6 ± 18.7 0.003 No
Insomnia 31.7 ± 31.1 30.2 ± 28.4 30.0 ± 23.9 42.8 ± 30.4 0.446 No 25.6 ± 22.4 31.6 ± 32.7 37.3 ± 26.3 0.077 No
Appetite loss 8.7 ± 18.6 19.3 ± 23.1 26.7 ± 29.8 42.8 ± 40.1 0.000 Yes 4.4 ± 11.4 18.5 ± 25.2 25.9 ± 28.4 0.000 Yes
Constipation 19.7 ± 28.2 29.4 ± 30.1 36.7 ± 32.3 33.3 ± 36.9 0.016 Yes 15.6 ± 28.4 27.7 ± 29.0 33.9 ± 32.4 0.001 Yes
Diarrhoea 7.8 ± 15.6 10.0 ± 16.5 16.7 ± 31.5 19.0 ± 25.2 0.221 No 4.4 ± 11.4 10.4 ± 18.4 15.2 ± 22.6 0.006 Yes
Financial difficulties 41.1 ± 35.6 55.2 ± 35.9 63.3 ± 35.7 80.9 ± 36.3 0.000 Yes 33.3 ± 36.8 54.2 ± 33.6 63.8 ± 38.8 0.000 Yes
CX24 Functional scales
Body image 22.9 ± 23.9 26.0 ± 22.3 31.1 ± 25.4 24.6 ± 14.6 0.286 No 22.4 ± 23.5 25.1 ± 21.2 27.9 ± 25.8 0.391 No
Sexual activity 7.1 ± 15.9 8.9 ± 15.5 6.7 ± 13.7 14.3 ± 17.1 0.216 No 7.2 ± 16.3 8.2 ± 15.0 9.6 ± 16.4 0.561 No
Sexual enjoyment (n = 80) 73.0 ± 35.5 52.4 ± 50.8 83.3 ± 19.2 77.8 ± 17.2 0.334 No 74.5 ± 33.9 58.1 ± 47.3 69.7 ± 37.9 0.429 No
Sexual/vaginal functioning (n = 72) 75.4 ± 26.2 69.7 ± 17.5 95.8 ± 4.8 83.3 ± 14.9 0.054 No 85.9 ± 13.9 60.0 ± 24.4 88.3 ± 13.1 0.000 Yes
CX24 Symptom scales
Symptom experience 12.7 ± 9.3 15.6 ± 15.1 14.2 ± 10.5 13.2 ± 9.0 0.901 No 10.9 ± 7.1 14.9 ± 14.0 15.7 ± 12.4 0.161 No
Lymphoedema 8.4 ± 20.7 8.9 ± 17.2 6.7 ± 13.7 14.3 ± 25.2 0.654 No 10.0 ± 21.5 8.7 ± 18.6 7.9 ± 16.8 0.974 No
Peripheral neuropathy 21.4 ± 21.3 24.1 ± 24.9 16.7 ± 17.0 23.8 ± 40.1 0.582 No 20.0 ± 23.9 23.8 ± 22.8 21.5 ± 26.8 0.345 No
Menopausal symptoms 24.6 ± 27.6 21.3 ± 22.4 13.3 ± 16.7 14.3 ± 25.2 0.221 No 22.2 ± 27.9 22.9 ± 23.8 18.1 ± 22.6 0.400 No
Sexual worry 16.2 ± 20.3 5.0 ± 16.0 16.7 ± 31.5 4.7 ± 12.1 0.000 Yes 14.4 ± 16.6 8.2 ± 17.5 11.3 ± 26.7 0.007 No

*Clinical relevance ≥10 points differences; S + C + R: surgery + chemotherapy + radiotherapy; C/R: chemotherapy and or radiotherapy.