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. 2018 Aug 10;8(8):77. doi: 10.1038/s41408-018-0114-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Heatmap of RNAseq data showing expression of individual MALT1 exons and corresponding joining sequences (red boxes: exon 7 and exon 7 joining sequences). Expression of full-length MALT1 correlates with expression of RBFOX2. b Expression array analysis (upper) and RT-PCR analysis (lower) revealed that increasing expression of RBFOX2 was paralleled by the full-length isoforms of MALT1, CLSTN1, FMNL3, and MYO9B. Exon numbering refers to the following sequences: MALT1 (NM_006785.3), CLSTN1 (NM_001009566), FMNL3 (ENST00000550488.5), MYO9B (NM_001130065). c Transfection with siRNA oligonucleotides efficiently downregulated expression of RBFOX2 mRNA (upper) and protein (medium). Repression of RBFOX2 resulted in an increase of the short isoforms of MALT1, FMNL3 and MYO9B (lower)